Papers: Epub ahead of print

  1. Circumferential wall enhancement in evolving intracranial aneurysms on magnetic resonance vessel wall imaging.
    Omodaka S, Endo H, Niizuma K, Fujimura M, Inoue T, Endo T, Sato K, Sugiyama SI, Tominaga T.
    J Neurosurg. doi: 10.3171/2018.5.JNS18322. [Epub ahead of print]

  2. What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review.
    Saqr KM, Rashad S, Tupin S, Niizuma K, Hassan T, Tominaga T, Ohta M.
    J Cereb Blood Flow Metab. doi: 10.1177/0271678X19854640. [Epub ahead of print]

  3. Unilateral chronic subdural hematoma due to spontaneous intracranial hypotension: a report of four cases.
    Osada Y, Shibahara I, Nakagawa A, Sakata H, Niizuma K, Saito R, Kanamori M, Fujimura M, Suzuki S, Tominaga T.
    Br J Neurosurg. doi: 10.1080/02688697.2019.1667482. [Epub ahead of print]

  4. A novel model of cerebral hyperperfusion with blood-brain barrier breakdown, white matter injury, and cognitive dysfunction.
    Mansour A, Rashad S, Niizuma K, Fujimura M, Tominaga T.
    J Neurosurg. doi: 10.3171/2019.7.JNS19212. [Epub ahead of print]

  5. Epigenetic response of endothelial cells to different wall shear stress magnitudes: A report of new mechano-miRNAs.
    Rashad S, Han X, Saqr K, Tupin S, Ohta M, Niizuma K, Tominaga T.
    J Cell Physiol. doi: 10.1002/jcp.29436. [Epub ahead of print]

  6. Optimal Timing of Extracranial-Intracranial Bypass with Microsurgical Trapping for Ruptured Blister Aneurysms of the Internal Carotid Artery.
    Endo H, Fujimura M, Shimizu H, Endo T, Omodaka S, Inoue T, Sato K, Niizuma K, Tominaga T.
    World Neurosurg. doi: 10.1016/j.wneu.2020.01.081. [Epub ahead of print]

  7. Symptomatic cerebral hyperperfusion following cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage: a case report.
    Sakata H, Endo H, Fujimura M, Niizuma K, Tominaga T.
    World Neurosurg. doi: 10.1016/j.wneu.2020.02.092. [Epub ahead of print]

  8. Regression of Recurrent Spinal Cord High-Grade Glioma After Convection-Enhanced Delivery of Nimustine Hydrochloride: Case Reports and Literature Review.
    Endo T, Inoue T, Sugiyama S, Saito R, Tominaga T.
    Oper Neurosurg (Hagerstown). doi: 10.1093/ons/opz172. [Epub ahead of print]

  9. Stress Induced tRNA Halves (tiRNAs) as Biomarkers for Stroke and Stroke Therapy; Pre-clinical Study. 
    Sato K, Rashad S, Niizuma K, Tominaga T. 
    Neuroscience. doi: 10.1016/j.neuroscience.2020.03.018. [Epub ahead of print]

Papers: 2020

  1. The hemodynamic complexities underlying transient ischemic attacks in early-stage Moyamoya disease: an exploratory CFD study.
    Rashad S, Saqr KM, Fujimura M, Niizuma K, Tominaga T.
    Sci Rep. 2020;10(1):3700. doi: 10.1038/s41598-020-60683-2.

  2. Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect.
    Sasaki T, Niizuma K, Kanoke A, Matsui K, Ogita S, Rashad S, Kawai T, Watanabe M, Endo H, Takahashi T, Kamakura S, Tominaga T.
    Heliyon. 2020;6(2):e03347. doi: 10.1016/j.heliyon.2020.e03347.

  3. Intravenously Transplanted Human Multilineage-Differentiating Stress-Enduring Cells Afford Brain Repair in a Mouse Lacunar Stroke Model.
    Abe T, Aburakawa D, Niizuma K, Iwabuchi N, Kajitani T, Wakao S, Kushida Y, Dezawa M, Borlongan CV, Tominaga T.
    Stroke. 2020;51(2):601-611. doi: 10.1161/STROKEAHA.119.026589.

Papers: 2019

  1. Experience of Low Dose Perampanel to Add-on in Glioma Patients with Levetiracetam-uncontrollable Epilepsy.
    Chonan M, Saito R, Kanamori M, Osawa SI, Watanabe M, Suzuki H, Nakasato N, Tominaga T.
    Neurol Med Chir (Tokyo). 2020;60(1):37-44. doi: 10.2176/nmc.oa.2018-0245.

  2. Cystic Glioblastoma Rupturing into the Ventricle.
    Sato Y, Saito R, Kanamori M, Tominaga T.
    NMC Case Rep J. 2019;7(1):39-41. doi: 10.2176/

  3. Arterial blood pressure correlates with 90-day mortality in sepsis patients: a retrospective multicenter derivation and validation study using high-frequency continuous data.
    Kobayashi N, Nakagawa A, Kudo D, Ishigaki T, Ishizuka H, Saito K, Ejima Y, Wagatsuma T, Toyama H, Kawaguchi T, Niizuma K, Ando K, Kurotaki K, Kumagai M, Kushimoto S, Tominaga T, Yamauchi M.
    Blood Press Monit. 2019;24(5):225-233. doi: 10.1097/MBP.0000000000000398.

  4. Genetic analysis of ring finger protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease.
    Tashiro R, Fujimura M, Sakata H, Endo H, Tomata Y, Sato-Maeda M, Niizuma K, Tominaga T.
    Neurol Res. 2019;41(9):811-816. doi: 10.1080/01616412.2019.1615726.

  5. Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study.
    Tashiro R, Niizuma K, Khor SS, Tokunaga K, Fujimura M, Sakata H, Endo H, Inoko H, Ogasawara K, Tominaga T.
    PLoS One. 2019;14(8):e0220858. doi: 10.1371/journal.pone.0220858.

  6. tiRNAs as a novel biomarker for cell damage assessment in in vitro ischemia-reperfusion model in rat neuronal PC12 cells.
    Elkordy A, Rashad S, Shehabeldeen H, Mishima E, Niizuma K, Abe T, Tominaga T.
    Brain Res. 2019;1714:8-17. doi: 10.1016/j.brainres.2019.02.019.

  7. Coexistence of Intracranial Germ Cell Tumor with Growing Arteriovenous Fistula.
    Ishida T, Endo H, Saito R, Kanamori M, Sato K, Matsumoto Y, Endo T, Fujimura M, Tominaga T.
    World Neurosurg. 2019;127:126-130. doi: 10.1016/j.wneu.2019.04.015. 

  8. Neuroprotective effects of minocycline and progesterone on white matter injury after focal cerebral ischemia.
    Faheem H, Mansour A, Elkordy A, Rashad S, Shebl M, Madi M, Elwy S, Niizuma K, Tominaga T.
    J Clin Neurosci. 2019;64:206-213. doi: 10.1016/j.jocn.2019.04.012.

  9. Cord Compression Caused by a Tangled and Warped Lumbar Catheter After Lumboperitoneal Shunt Placement.
    Sato K, Endo T, Sakata H, Inoue T, Niizuma K, Tominaga T.
    Neurospine. 2019;16(2):368-372. doi: 10.14245/ns.1836114.057.

  10. Transsphenoidal Removal of Retroclival Chondroma with Pituitary Transposition Manifesting as Repeated Subarachnoid Hemorrhage: A Case Report.
    Ogawa Y, Niizuma K, Tominaga T.
    J Neurol Surg A Cent Eur Neurosurg. 2019;80(3):228-232. doi: 10.1055/s-0038-1677452.

  11. Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage.
    Inoue T, Ishida T, Inoue T, Saito A, Ezura M, Uenohara H, Fujimura M, Sato K, Endo T, Omodaka S, Endo H, Niizuma K, Tominaga T.
    J Stroke Cerebrovasc Dis. 2019;28(2):490-494. doi: 10.1016/j.jstrokecerebrovasdis.2018.10.027.

  12. Significance of Quantitative Cerebral Blood Flow Measurement in the Acute Stage after Revascularization Surgery for Adult Moyamoya Disease: Implication for the Pathological Threshold of Local Cerebral Hyperperfusion.
    Kameyama M, Fujimura M, Tashiro R, Sato K, Endo H, Niizuma K, Mugikura S, Tominaga T.
    Cerebrovasc Dis. 2019;48(3-6):217-225. doi: 10.1159/000504835.

  13. Incidence and Risk Factors of the Watershed Shift Phenomenon after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis for Adult Moyamoya Disease.
    Tashiro R, Fujimura M, Kameyama M, Mugikura S, Endo H, Takeuchi Y, Tomata Y, Niizuma K, Tominaga T.
    Cerebrovasc Dis. 2019;47(3-4):178-187. doi: 10.1159/000500802.

  14. Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI.
    Shibahara I, Saito R, Osada Y, Kanamori M, Sonoda Y, Kumabe T, Mugikura S, Watanabe M, Tominaga T.
    J Neurooncol. 2019;141(2):337-345. doi: 10.1007/s11060-018-03036-4.

Papers: 2018

  1. Mechanical Thrombectomy for Acute Ischemic Stroke Arising from Thrombus of the Left Superior Pulmonary Vein Stump after Left Pneumonectomy: A Case Report.
    Sonobe S, Yoshida M, Niizuma K, Tominaga T.
    NMC Case Rep J. 2018;6(1):17-20. doi: 10.2176/

  2. Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.
    Fukuoka K, Saito R et al.; Japan Pediatric Molecular Neuro-Oncology Group (JPMNG).
    Acta Neuropathol Commun. 2018;6(1):134. doi: 10.1186/s40478-018-0630-1.

  3. Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis.
    Rashad S, Niizuma K, Sato-Maeda M, Fujimura M, Mansour A, Endo H, Ikawa S, Tominaga T.
    Brain Res. 2018;1699:54-68. doi: 10.1016/j.brainres.2018.06.029.

  4. Biphasic Development of Focal Cerebral Hyperperfusion After Revascularization Surgery for Adult Moyamoya Disease Associated With Autosomal Dominant Polycystic Kidney Disease.
    Tashiro R, Fujimura M, Endo H, Endo T, Niizuma K, Tominaga T.
    J Stroke Cerebrovasc Dis. 2018;27(11):3256-3260. doi: 10.1016/j.jstrokecerebrovasdis.2018.07.024.

  5. Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging.
    Abe T, Niizuma K, Kanoke A, Saigusa D, Saito R, Uruno A, Fujimura M, Yamamoto M, Tominaga T.
    Neurol Med Chir (Tokyo). 2018;58(9):384-392. doi: 10.2176/nmc.oa.2018-0054.

  6. A refined model of chronic cerebral hypoperfusion resulting in cognitive impairment and a low mortality rate in rats.
    Mansour A, Niizuma K, Rashad S, Sumiyoshi A, Ryoke R, Endo H, Endo T, Sato K, Kawashima R, Tominaga T.
    J Neurosurg. 2018;131(3):892-902. doi: 10.3171/2018.3.JNS172274.

  7. Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells.
    Elkordy A, Mishima E, Niizuma K, Akiyama Y, Fujimura M, Tominaga T, Abe T.
    J Neurochem. 2018;146(5):560-569. doi: 10.1111/jnc.14321.

  8. Paradoxical Association of Symptomatic Local Vasogenic Edema with Global Cerebral Hypoperfusion after Direct Revascularization Surgery for Adult Moyamoya Disease.
    Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T.
    J Stroke Cerebrovasc Dis. 2018;27(8):e172-e176. doi: 10.1016/j.jstrokecerebrovasdis.2018.03.002.

  9. Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia.
    Rashad S, Niizuma K, Saigusa D, Han X, Sato-Maeda M, Saito R, Uruno A, Fujimura M, Ikawa S, Yamamoto M, Tominaga T.
    Neuroscience. 2018;384:188-202. doi: 10.1016/j.neuroscience.2018.05.015.

  10. [Surgical Planning for a Giant Pituitary Adenoma Based on Evaluation of the Fine Feeding System and Angioarchitecture:A Case Report].
    Ogawa Y, Jokura H, Niizuma K, Tominaga T.
    No Shinkei Geka. 2018;46(8):691-697. doi: 10.11477/mf.1436203795. Japanese.

  11. Mid-term prognosis of non-functioning pituitary adenomas with high proliferative potential: really an aggressive variant?
    Ogawa Y, Jokura H, Niizuma K, Tominaga T.
    J Neurooncol. 2018;137(3):543-549. doi: 10.1007/s11060-017-2740-1.

  12. Circumferential Wall Enhancement on Magnetic Resonance Imaging is Useful to Identify Rupture Site in Patients with Multiple Cerebral Aneurysms.
    Omodaka S, Endo H, Niizuma K, Fujimura M, Endo T, Sato K, Sugiyama SI, Inoue T, Tominaga T.
    Neurosurgery. 2018;82(5):638-644. doi: 10.1093/neuros/nyx267.

  13. Impact of bifurcation angle and inflow coefficient on the rupture risk of bifurcation type basilar artery tip aneurysms.
    Rashad S, Sugiyama SI, Niizuma K, Sato K, Endo H, Omodaka S, Matsumoto Y, Fujimura M, Tominaga T.
    J Neurosurg. 2018;128(3):723-730. doi: 10.3171/2016.10.JNS161695.

  14. Clinical Characteristics of Lumbosacral Spinal Dural Arteriovenous Fistula (DAVF)-Comparison with Thoracic DAVF.
    Endo T, Kajitani T, Inoue T, Sato K, Niizuma K, Endo H, Matsumoto Y, Tominaga T.
    World Neurosurg. 2018;110:e383-e388. doi: 10.1016/j.wneu.2017.11.002.

  15. Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis.
    Fujimura M, Fujimura T, Kakizaki A, Sato-Maeda M, Niizuma K, Tomata Y, Aiba S, Tominaga T.
    Brain Res. 2018;1679:39-44. doi: 10.1016/j.brainres.2017.11.013.

  16. Embolization of ruptured arteriovenous malformations in the cerebellopontine angle cistern.
    Endo H, Osawa SI, Matsumoto Y, Endo T, Sato K, Niizuma K, Fujimura M, Tominaga T.
    Neurosurg Rev. 2018;41(1):173-182. doi: 10.1007/s10143-017-0832-1.

  17. Patient with Recurrent Anterior Cerebral Artery Dissecting Aneurysm After Stent-Assisted Coil Embolization Successfully Treated with A3-A3 Anastomosis.
    Takahashi Y, Endo H, Endo T, Fujimura M, Niizuma K, Tominaga T.
    World Neurosurg. 2018;109:77-81. doi: 10.1016/j.wneu.2017.09.128.

Review articles

  1. tRNA cleavage: a new insight.
    Rashad S, Niizuma K, Tominaga T.
    Neural Regen Res. 2020;15(1):47-52. doi: 10.4103/1673-5374.264447.

  2. [Actualization of Neural Regenerative Medicine by Intravenous Drip of Donor-derived Muse Cells].
    Dezawa M, Niizuma K, Tominaga T.
    BRAIN and NERVE. 2019;71(8):895-900. doi: 10.11477/mf.1416201372.

  3. 未破裂脳動脈瘤診療の実際
    Geriat Med. 2019;57(5),469-474. ISSN: 0387-1088. Japanese.

  4. 脳梗塞におけるMuse細胞を用いた治用戦略
    新妻邦泰, 冨永悌二
    血液フロンティア. 2019;29(2):47-57. doi: 10.20837/5201902185. Japanese.

  5. Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework and Guidelines on Development of Cell-Based Products.
    Houkin K, Shichinohe H, Abe K, Arato T, Dezawa M, Honmou O, Horie N, Katayama Y, Kudo K, Kuroda S, Matsuyama T, Miyai I, Nagata I, Niizuma K, Sakushima K, Sasaki M, Sato N, Sawanobori K, Suda S, Taguchi A, Tominaga T, Yamamoto H, et al.
    Stroke. 2018;49(4):e145-e152. doi: 10.1161/STROKEAHA.117.019216.

  6. CEAとCASの適応と課題
    遠藤英徳, 藤村幹, 松本康史, 遠藤俊毅, 佐藤健一, 新妻邦泰, 井上敬, 冨永悌二
    脳神経外科ジャーナル. 2018;27(7):514-521. doi: 10.7887/jcns.27.514. Japanese.

  7. 脳卒中モデルに対するMuse細胞移植の効果
    内田浩喜, 新妻邦泰, 出澤真理, 冨永悌二
    Clinical Neuroscience. 2018;36(3):356-360. ISSN: 0289-0585. Japanese.



  1. Application of Muse Cell Therapy to Stroke.
    Niizuma K, Borlongan CV, Tominaga T.
    Adv Exp Med Biol. 2018;1103:167-186. doi: 10.1007/978-4-431-56847-6_9.

  2. 2 頭蓋内脳動脈瘤 2 後交通動脈瘤
    脳血管内治療ケーススタディ 広南流20の戦略, pp.18-30, 中外医学社, 東京, 2018.ISBN: 978-4-498-32826-6. Japanese.

  3. 9 脳腫瘍塞栓
    脳血管内治療ケーススタディ 広南流20の戦略, pp.212-228, 中外医学社, 東京, 2018.ISBN: 978-4-498-32826-6. Japanese.

  4. 開頭手術と血管内治療の複合治療 4 dAVF 横静脈洞-S状静脈洞部dAVF
    新妻邦泰, 遠藤英徳, 松本康史, 冨永悌二
    脳神経外科速報増刊 Hybrid Neurosurgeonのための疾患別臨床脳血管解剖テキスト, pp.254-264, メディカ出版, 東京, 2018. ISBN: 978-4-8404-6309-6. Japanese.

  5. 第III部 各論 20 創薬の実際
    新妻邦泰, 冨永悌二
    脳卒中病態学のススメ, pp.323-331, 南山堂, 東京, 2018. ISBN: 978-4-525-24851-2. Japanese.